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Introducing Letybo: Advanced Results with Trusted Expertise

At The Maas Clinic in San Francisco, excellence meets innovation. Led by internationally acclaimed facial plastic surgeon Corey S. Maas, MD, FACS, our clinic delivers sophisticated, science-driven treatments with artistry and integrity. Now offering Letybo, an advanced injectable treatment for glabellar lines, we continue to uphold our commitment to only the most rigorously tested, globally trusted therapies. 

Dr. Maas directly participated in Letybo’s clinical trials, placing The Maas Clinic at the forefront of introducing this groundbreaking injectable to the U.S. aesthetic market.

If you're considering neuromodulators to refresh your look, we invite you to book your consultation today and experience The Maas Clinic's refined expertise.

Letybo Overview

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Explaining LETYBO

Letybo is a globally trusted aesthetic injectable clinically proven to reduce the appearance of moderate to severe glabellar lines (frown lines between the eyebrows). It is the #1 neurotoxin in South Korea and has been approved in over 65 countries, with more than 31 million vials sold worldwide. Now FDA-approved and available in the U.S., Letybo offers rapid onset, consistent outcomes, and a well-established safety profile validated by three global Phase III trials.

    Why Choose The Maas Clinic for Letybo Injections?

    With a foundation built on leadership, research, and surgical precision, The Maas Clinic delivers world-class injectable treatments in a serene, luxurious setting. Letybo offers a compelling alternative to other well-known neuromodulators like BOTOX and Dysport, giving patients another powerful option for facial rejuvenation.

    Dr. Corey Maas’s participation in Letybo’s international clinical trials reflects his standing as a pioneer in aesthetic medicine and his dedication to the advancement of facial rejuvenation therapies. Our clinic pairs that research legacy with deeply personalized patient care, ensuring every injection enhances your natural beauty while prioritizing your comfort and safety.

    Benefits of Letybo Injections

    Letybo offers a refined approach to softening lines—bringing you natural-looking results, renewed confidence, and more. Here’s what you can expect:

    • Smoother skin, quickly: Many patients notice visible softening of frown lines as early as the first day, with full results typically showing within 3 days.
    • Lasting confidence: Enjoy refreshed, natural-looking results that last up to four months with a single treatment.
    • Trusted worldwide: Over 31 million vials sold globally and now FDA-approved in the U.S.
    • Clinically proven performance: Shown to reduce moderate to severe glabellar lines significantly in international studies.
    • Low risk of side effects: Minimal downtime and a low chance of eyelid or brow drooping (under 1%).
    • No buildup of resistance: Clinical trials found no neutralizing antibodies, even with repeated use.
    • A comfortable, efficient experience: Quick in-office treatment with no anesthesia required and no disruption to your day.
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    Am I a Good Candidate for Letybo?

    Letybo may be ideal for adults seeking to reduce moderate to severe frown lines without invasive procedures. You may be a good candidate if you:

    • Are in overall good health
    • Are not pregnant or nursing
    • Have realistic expectations
    • Prefer subtle, natural-looking facial rejuvenation
    • Are seeking a safe, non-surgical way to reduce frown lines

    During your consultation at The Maas Clinic we will assess your goals and medical history to determine if Letybo is the right fit for you.

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    “Dr. Maas is an amazing injector and surgeon. I’ve been going to see him for a long time, he’s got a great team and is highly professional. Dr Maas has a special gift for helping you look your best.” - S.S.

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    Your Treatment Experience

    Your treatment begins with a detailed aesthetic assessment from one of our expert providers. Injections take just minutes to perform and involve minimal discomfort. We use ultra-fine needles and meticulous technique to ensure your treatment is as comfortable and precise as possible. You may return to normal activities immediately after the procedure.

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    Aftercare and What to Expect


    Letybo requires little to no downtime. Some patients experience minor redness or swelling at the injection sites, which typically resolves within hours. Results often begin to appear within 24 to 72 hours, with full smoothing effects visible by Week 4. Most patients enjoy results that last approximately four months, after which maintenance treatments can be scheduled to preserve your refreshed appearance.

    LETYBO FAQ

    How does Letybo interact with other cosmetic procedures like laser treatments or microneedling?

    Can I receive Letybo injections if I’ve developed resistance to other neuromodulators?

    What happens if I stop using Letybo after multiple treatments?

    Are there any long-term risks associated with repeated Letybo injections?

    Is Letybo safe for people with autoimmune conditions?

    How should I prepare for my Letybo appointment?

    How should I prepare for my Letybo appointment?

    Can men benefit from Letybo injections?

    Is Letybo suitable for treating areas beyond the glabella?

    Can I work out after getting Letybo injections?

    How does Letybo interact with other cosmetic procedures like laser treatments or microneedling?

    Letybo can often be safely combined with other cosmetic treatments such as laser procedures or microneedling, but the timing and order of treatments matter. We recommend spacing procedures to avoid irritation or reduced efficacy. Your provider will create a tailored plan.

    Can I receive Letybo injections if I’ve developed resistance to other neuromodulators?

    While rare, some individuals develop resistance to certain neurotoxins. Letybo has shown no neutralizing antibodies in clinical trials, suggesting low likelihood of resistance, but we will evaluate your treatment history during consultation.

    What happens if I stop using Letybo after multiple treatments?

    If you discontinue Letybo, your muscles will gradually regain movement, and dynamic wrinkles may reappear. However, your skin will not worsen as a result of stopping treatment.

    Are there any long-term risks associated with repeated Letybo injections?

    Current research and clinical data, including trials Dr. Maas participated in, show no serious long-term risks with repeated Letybo use. However, as with any injectable, it’s essential to work with a qualified provider to avoid overuse.

    Is Letybo safe for people with autoimmune conditions?

    Letybo has not been extensively studied in patients with autoimmune disorders. If you have such a condition, we will thoroughly review your medical history to assess suitability and ensure your safety.

    How should I prepare for my Letybo appointment?

    To reduce the risk of bruising, avoid alcohol, aspirin, or anti-inflammatory medications for 24–48 hours before your visit. Arrive with a clean face and share any recent changes in medications or health.

    How should I prepare for my Letybo appointment?

    To reduce the risk of bruising, avoid alcohol, aspirin, or anti-inflammatory medications for 24–48 hours before your visit. Arrive with a clean face and share any recent changes in medications or health.

    Can men benefit from Letybo injections?

    Absolutely. Letybo is equally effective for men and women. Many male patients use neuromodulators to soften frown lines and maintain a relaxed, approachable appearance without feminizing their features.

    Is Letybo suitable for treating areas beyond the glabella?

    Letybo is FDA-approved for glabellar lines but may be used off-label in other areas by experienced injectors. Our providers will determine if Letybo is appropriate for your broader aesthetic goals.

    Can I work out after getting Letybo injections?

    Strenuous exercise should be avoided for 24 hours after treatment to minimize product migration and bruising. Light activity is usually fine, but we recommend discussing your routine with your provider.

    Why Choose Dr. Maas? 


    Choosing Dr. Corey Maas from The Maas Clinic means selecting a world-class expert with over 30 years of experience and more than 3,000 rhinoplasty surgeries performed. Dr. Maas is double board-certified in California and Florida and has earned prestigious accolades, including Best Cosmetic Surgeon by the SF Examiner and SF Weekly. He is also a leader in non-surgical treatments like BOTOX®, offering patients a safe, effective solution to reduce wrinkles and achieve a youthful appearance. For over two decades, Dr. Maas has served as a fellowship director for The Fellowship Program, supported by the Educational and Research Foundation of the American Academy of Facial Plastic and Reconstructive Surgery. His personalized care and innovative techniques make him a trusted choice for surgical and non-surgical facial rejuvenation.

    Learn More About His Experience

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